BEMÆRK: Ansøgningsfristen er overskredet
Faculty of Health and Medical Sciences, University of Copenhagen
We are looking for a highly motivated and dynamic postdoc for a 2-year position, position commencing 15 October 2023 or as soon as possible hereafter. Within these two years, the successful candidate will develop novel on-demand turn-on fluorophores for image guide surgery purposes.
Our research
The Herth group´s research focusses on the development of pretargeted strategies based on the tetrazine ligation. The group consist currently of 10 members (4 PostDocs, 3 PhDs, and 3 Master students).
Your job
On-demand fluorophore activation is a tool in chemical biology for investigating subcellular structures and dynamics. The tetrazine (Tz) ligation has become a staple in this regard due to its rapid kinetics and high turn-on ratios. This is achieved by utilizing Förster resonance energy transfer-based quenching from the fluorophores to the Tz moiety, which is lost upon the ligation. Due to the inherent properties of the Tz, a rapid drop-off in turn-on ratios for redshifted fluorophores with emission wavelengths of 710 nm was observed. This makes Tzs unsuitable for quenching fluorophores in the near infrared region (NIR) (800 nm). As these wavelengths have typically to be used in vivo to achieve sufficient tissue penetration, this leaves a huge gap in translating this concept into humans. The aim of this project is to overcome these limitations and develop an instant click and release Tz, which lead to unprecedented turn-on ratios for NIR-dyes.
Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:
Essential experience and skills:
- You have a PhD in medicinal chemistry, organic chemistry or radiopharmaceutical chemistry
- You are highly experienced in medicinal chemistry approaches and organic synthesis
- You have an active interest in click chemistry and their in vivo applications
- Proficient communication skills and ability to work in teams
- Excellent English skills written and spoken
- Knowledge about tetrazine based click chemistry
- Experience in radiopharmaceutical chemistry
The place of employment is at the Department of Drug Design and Pharmacology, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and imaging facilities.
Terms of employment
The average weekly working hours are 37 hours per week.
The position is a fixed-term position limited to a period of 2 years. The starting date is 15 October 2023 or after agreement.
Salary, pension and other conditions of employment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations) or other relevant organisation. Currently, the monthly salary starts at 36,000 DKK/approx. 4,800 EUR (April 2023 level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.
Foreign and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the Job Structure for Academic Staff at Universities 2020.
Questions
For further information please contact Assoc. Prof. Matthias Herth; matthias.herth@sund.ku.dk; www.sund.ku.dk
Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:
- Motivated letter of application (max. one page).
- CV incl. education, work/research experience, language skills and other skills relevant for the position.
- A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
- List of publications.
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.
The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
Interviews are expected to be held in August.
The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.
INFORMATIONER OM STILLINGEN:
- Arbejdspladsen ligger i:
Gladsaxe Kommune
-Virksomheden tilbyder:
-Arbejdsgiver:
KU - SUND - Kbh Ø , Institut for Farmaci, Universitetsparken 2, 2100 København Ø
-Ansøgning:
Ansøgningsfrist: 23-08-2023; - ansøgningsfristen er overskredet
Ved skriftlig henvendelse: https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1307&ProjectId=159773&DepartmentId=19218&MediaId=4632&SkipAdvertisement=true
Se mere her: https://job.jobnet.dk/CV/FindWork/Details/5883859